Exposure-based Chemical Priority Setting in the 21st Century
This online engineering PDH interactive presentation provides a detailed exploration of modern approaches to chemical risk assessment and prioritization in the 21st century. It emphasizes the importance of evaluating thousands of chemicals in commerce through New Approach Methodologies (NAMs), which combine hazard identification, exposure forecasting, and toxicokinetics. The presentation highlights best practices for chemical prioritization using high-throughput screening, biomonitoring data integration, machine learning, and risk-based ranking strategies.
This presentation begins by introducing the challenges in traditional chemical risk assessment and the evolving regulatory landscape. It delves into the use of ToxCast, ExpoCast, and HTTK tools for high-throughput hazard, exposure, and toxicokinetic modeling. Participants will gain insights into IVIVE (in vitro-in vivo extrapolation), demographic and life-stage exposure variations, and Bayesian modeling frameworks like SEEM. Additionally, the presentation covers exposure modeling, data transparency, and the use of publicly available dashboards and R packages to support decision-making. Real-world examples illustrate how machine learning and statistical methods are transforming the future of chemical safety.
This 1 PDH online interactive presentation is designed for environmental engineers, chemical safety professionals, toxicologists, public health analysts, and regulatory personnel seeking to advance their understanding of chemical risk assessment, prioritize chemical safety testing, and improve public health protection through innovative exposure science.
This continuing education interactive presentation is intended to provide you with the following specific knowledge and skills:
- To discuss the challenges and opportunities in chemical risk assessment and prioritization for thousands of chemicals in modern commerce.
- To understand the regulatory framework, data gaps, and emerging needs that led to the development of New Approach Methodologies (NAMs) for chemical evaluation.
- To explore high-throughput hazard, exposure, and toxicokinetic methods (e.g., ToxCast, ExpoCast, HTTK) that enable rapid chemical prioritization.
- To familiarize with in vitro-in vivo extrapolation, risk-based ranking, and the integration of biomonitoring and exposure modeling data.
- To learn about demographic and life-stage variations in chemical exposure and their implications for public health decision-making.
- To gain insights into the role of machine learning, Bayesian frameworks, and data transparency in advancing chemical risk assessment and protecting human health.
Once you finish watching the PDH interactive presentation, you will be redirected to your account to take a multiple-choice quiz consisting of (10) questions to earn 1 PDH credit.
Upon successful completion of the quiz, print your Certificate of Completion instantly. (Note: if you are paying by check or money order, you will be able to print it after we receive your payment.) For your convenience, we will also email it to you. Please note that you can log in to your account at any time to access and print your Certificate of Completion.